Simulated Internal Medicine Patient Learning Experience (SIMPLE) is an Internet-based virtual patient program for use by medical students during their internal medicine clerkship. Through an extensively collaborative authoring, editing, and peer-review process, SIMPLE’s 36 interactive virtual patient cases cover the learning objectives of the Clerkship Directors in Internal Medicine (CDIM)-Society for General Internal Medicine Core Medicine Clerkship Curriculum Guide Version 3.0 comprehensively.